Premium
A Copper Coordination Compound Produced by a Marine Fungus Fusarium sp. ZZF51 with Biosorption of Cu(II) Ions
Author(s) -
TAN Ni,
PAN JiaHui,
PENG GuangTian,
MOU ChengBo,
TAO YiWen,
SHE ZhiGang,
YANG ZeLiang,
ZHOU ShiNing,
LIN YongCheng
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890097
Subject(s) - chemistry , biosorption , copper , bacillus subtilis , nuclear chemistry , fungus , botany , bacteria , organic chemistry , sorption , adsorption , biology , genetics
A copper coordination compound ZZF51(A) named bis(5‐butyl‐2‐pyridinecarboxylato‐N1,O2)‐copper, the first time found in the nature, was isolated from a marine endophytic fungus Fusarium sp. ZZF51 from the South China Sea coast. Its structure was elucidated using spectroscopic methods and single crystal X‐ray diffraction analysis. The antimicrobial cytotoxicity experiments exhibited that ZZF51(A) had mutagenicity activities against four aerobic reference strains Staphylococcus aureus , Bacillus subtilis , Escherichia coli , and Salmonella enteritidis with respective MIC values of 12.5, 25, 12.5, and 50 µg/mL. The anti‐cancer tests showed that the compound had strong inhibitory activities against three human cancer lines KB, KBv200, and HepG2 with IC 50 values of 3.54, 3.68 and 25.12 µg/mL respectively. In the course of investigating the source of ZZF51(A) in biomass, it was found that the output of ZZF51(A) was largely influenced by the amount of CuCl 2 in the liquid medium, and the fungus (No. ZZF51) had two notable characteristics:endurance of high concentration Cu(II) ions and biosorption of Cu(II) ions.