Premium
Photobleaching of Hypocrellin B and 2‐Taurine Substituted Hypocrellin B in Plasma Solution
Author(s) -
DING HuiYing,
ZHANG Yang,
GU Ying,
ZHAO JingQuan
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890096
Subject(s) - photobleaching , chemistry , photosensitizer , singlet oxygen , photochemistry , photodynamic therapy , aqueous solution , biomolecule , biophysics , oxygen , fluorescence , organic chemistry , biochemistry , physics , quantum mechanics , biology
Photodynamic therapy (PDT) is a new methodology to utilize jointly a photosensitizer and light to destroy the target tissues of diseases via some photochemical reactions. On the other hand, the photosensitizer molecules may also be photo‐bleached during PDT, furthermore, their interaction with biomolecules and the photobleaching properties in blood vessels are critical to treatments of microvascular diseases. In consideration of these, the photobleaching processes of HB and its analogue THB in plasma solutions were investigated in the current work. It was observed that the photobleaching was predominately mediated by singlet oxygen reactions in well‐oxygenated aqueous solution in the presence of plasma substrate which not only greatly enhanced the photobleaching rate but also led to different photoproducts due to distinctly different reaction mechanisms. The relative photobleaching mechanisms were proposed based on the structural information and the redox potentials of the photosensitizers.