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Synthesis, Characterization and Antibacterial Activity of New 5‐( o ‐Chlorophenyl)‐3‐( o , p ‐dichlorophenyl)‐4,5‐dihydropyrazol‐1‐yl Oxime Ester Derivatives
Author(s) -
LIU XinHua,
SONG BaoAn,
ZHU HaiLiang,
ZUO RenBing
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890095
Subject(s) - chemistry , dna gyrase , bacillus subtilis , oxime , antibacterial activity , minimum inhibitory concentration , escherichia coli , staphylococcus aureus , pseudomonas aeruginosa , in vitro , bacteria , stereochemistry , proton nmr , carbon 13 nmr , medicinal chemistry , biochemistry , genetics , biology , gene
Ten new 1‐(5‐(2‐chlorophenyl)‐3‐(2,4‐dichlorophenyl)‐4,5‐dihydropyrazol‐1‐yl) oxime ester derivatives were synthesized and characterized by elemental analysis, HRMS and 1 H NMR data. All the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa . The results show that 7c and 7f possess significant activity with the minimum inhibitory concentrations (MIC) value of 1.562 µg/mL against all the four bacteria. Compounds 7c , 7d and 7f show moderate inhibition against the DNA gyrase (IC 50 =1.6–2.5 µg/mL). On the basis of the biological result, the structure‐activity relationship was discussed.