Synthesis, Characterization and Antibacterial Activity of New 5‐( o ‐Chlorophenyl)‐3‐( o , p ‐dichlorophenyl)‐4,5‐dihydropyrazol‐1‐yl Oxime Ester Derivatives | Zendy

LIU XinHua | Zendy; SONG BaoAn | Zendy; ZHU HaiLiang | Zendy; ZUO RenBing | Zendy

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Synthesis, Characterization and Antibacterial Activity of New 5‐( o ‐Chlorophenyl)‐3‐( o , p ‐dichlorophenyl)‐4,5‐dihydropyrazol‐1‐yl Oxime Ester Derivatives

Author(s) -

LIU XinHua,

SONG BaoAn,

ZHU HaiLiang,

ZUO RenBing

Publication year - 2008

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200890095

Subject(s) - chemistry , dna gyrase , bacillus subtilis , oxime , antibacterial activity , minimum inhibitory concentration , escherichia coli , staphylococcus aureus , pseudomonas aeruginosa , in vitro , bacteria , stereochemistry , proton nmr , carbon 13 nmr , medicinal chemistry , biochemistry , genetics , biology , gene

Ten new 1‐(5‐(2‐chlorophenyl)‐3‐(2,4‐dichlorophenyl)‐4,5‐dihydropyrazol‐1‐yl) oxime ester derivatives were synthesized and characterized by elemental analysis, HRMS and 1 H NMR data. All the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa . The results show that 7c and 7f possess significant activity with the minimum inhibitory concentrations (MIC) value of 1.562 µg/mL against all the four bacteria. Compounds 7c , 7d and 7f show moderate inhibition against the DNA gyrase (IC 50 =1.6–2.5 µg/mL). On the basis of the biological result, the structure‐activity relationship was discussed.

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