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An Environmentally Benign Access to Dimethylated 1,6‐Dihydropyrimidines Using Dimethyl Carbonate as Methylating Agent under Microwave
Author(s) -
WANG XiCun,
QUAN ZhengJun,
ZHANG Zhang
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890071
Subject(s) - chemistry , dimethyl carbonate , dimethyl sulfate , environmentally friendly , reagent , halide , organic chemistry , bromide , methylation , microwave , carbonate , methanol , biochemistry , ecology , physics , quantum mechanics , gene , biology
An environmentally benign procedure for dimethylated 1,6‐dihydropyrimidines has been developed by the reaction of 1,2,3,4‐tetrahydropyrimidine‐2‐thiones with dimethyl carbonate, a non‐toxic and environmentally friendly reagent. The methylation of 1,2,3,4‐tetrahydropyrimidine‐2‐thione was promoted by MgO and tetrabutylammonium bromide (TBAB) under microwave. This protocol avoids the use of strong bases and highly toxic methylating agents such as methyl halide or dimethyl sulfate. Additionally, the possible role of MgO/TBAB in the reaction was also presented.