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Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Ru Complex Using a New Bipyridyl Diphosphine
Author(s) -
CHEN Li,
FU XingLi,
MING FangYong,
CHEN Hua,
LI XianJun
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890068
Subject(s) - chemistry , enantioselective synthesis , catalysis , noyori asymmetric hydrogenation , asymmetric hydrogenation , solvent , organic chemistry , diamine , ketone , medicinal chemistry , combinatorial chemistry
A series of RuCl 2 (bipyridyldiphosphine)(1,2‐diamine) complexes were synthesized and applied to the asymmetric hydrogenation of aromatic ketones. Solvent effect and a wide variety of aromatic ketones were explored and up to 96% enantioselectivity was achieved in the hydrogenation of o ‐bromoacetophenone.
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