Premium
C 60 ‐Based Ebselen Derivative: Synthesis and Enhanced Protective Effect on Mouse Thymus Cells
Author(s) -
LIU XuFeng,
GUAN WenChao,
KE WenShan
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890030
Subject(s) - ebselen , chemistry , derivative (finance) , malonate , yield (engineering) , stereochemistry , ethanol , medicinal chemistry , organic chemistry , materials science , glutathione peroxidase , financial economics , economics , metallurgy , glutathione , enzyme
A C 60 ‐based ebselen derivative 3 was synthesized through a Bingel cyclopropanation of C 60 with the ebselen malonate 2 . It was obtained in a three‐step synthesis starting from 2‐(chloroseleno)benzoyl chloride and 2‐(2‐aminoethoxy)ethanol, in a 42% yield (based on consumed C 60 ). Its structure was characterized by 1 H NMR, 13 C NMR, IR, FAB‐MS, and elemental analyses techniques. To verify that the C 60 ‐based ebselen derivative 3 had enhanced effect on viability of mouse thymus cells, the C 60 derivative 4 and ebselen derivative 2 were selected to treat the mouse thymus cells using the same procedures as those with the C 60 ‐based ebselen derivative 3 . The result shows that MTT(OD) values of compound 3 treated groups (0.335±0.021) were all higher than those of compound 4 (0.283±0.031) and compound 2 (0.247±0.025) treated groups, indicating that the compound 3 has an advantage over compounds 2 and 4 in promoting the viability of the mouse thymus cell.