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Iodine Catalyzed One‐pot Synthesis of 3,4‐Dihydroquinazolin‐4‐ones from Anthranilic Acids, Ortho Esters and Amines under Solvent‐free Conditions
Author(s) -
WANG HongShe,
ZENG JunE
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890017
Subject(s) - chemistry , catalysis , solvent , iodine , anthranilic acid , organic chemistry , combinatorial chemistry , reaction conditions
A simple and efficient procedure has been developed for the one‐pot synthesis of 3,4‐dihydroquinazolin‐4‐ones from anthranilic acids, ortho esters and amines using a catalytic amount of iodine under solvent‐free conditions to afford the corresponding products in excellent yields. The direct use of commercially available catalyst, mild and solvent‐free reaction conditions, short reaction time, easy workup and excellent yields are the advantages of the present protocol.