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Synthesis of Certain 3‐Aminopyrazolo[5,4‐ b ]pyridine and 3,4‐Substituted Pyrido[2′,3′ :3,4]pyrazolo[5,1‐ c ][1,2,4]triazine Derivatives
Author(s) -
ELLOUH Ali Khader Khalil,
ABUNADA Nada Mohamed,
ELSHOUBAKI Mohamed
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790348
Subject(s) - chemistry , pyrazole , hydrazine (antidepressant) , hydrate , methylene , triazine , pyridine , medicinal chemistry , methyl iodide , iodide , organic chemistry , chromatography
2‐Thioxo‐1,2‐dihydropyridine derivatives 2a , 2b were reacted with methyl iodide to give 2‐methylthiopyridines 3a , 3b , which were reacted with hydrazine hydrate to produce 3‐aminopyrazolo[5,4‐ b ]pyridines 4a , 4b . Compounds 4a , 4b were diazotized to afford the corresponding diazonium salts 5a , 5b , which were reacted with some active methylene compounds 6a – 6h to give the corresponding pyrido[2′,3′:3,4]pyrazole[5,1‐ c ][1,2,4]triazines 7 – 14 .