A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides | Zendy

SUN Xun | Zendy; ZHU Jun | Zendy; ZHONG Chen | Zendy; IZUMI KenJi | Zendy; ZHANG Chen | Zendy

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A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides

Author(s) -

SUN Xun,

ZHU Jun,

ZHONG Chen,

IZUMI KenJi,

ZHANG Chen

Publication year - 2007

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200790344

Subject(s) - chemistry , toluene , resveratrol , wittig reaction , combinatorial chemistry , organic chemistry , biochemistry

A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron‐withdrawing group(s) by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig‐Horner reaction and a rearrangement in the presence of t ‐BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimethoxystilbenes 1 ( Z ) and 2 ( E ).

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