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A Convenient and Efficient Route to 1,4‐Bis(heteroaryl)‐ buta‐1,3‐diene and 4‐Heteroarylbut‐1‐en‐3‐yne from 1,4‐Dichlorobut‐2‐yne
Author(s) -
ZHANG XiaoMing,
WU GuoQiang,
CHEN WanZhi
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790318
Subject(s) - chemistry , imidazole , diene , indole test , pyrrole , pyrazole , conjugated system , medicinal chemistry , combinatorial chemistry , organic chemistry , natural rubber , polymer
Abstract A convenient and practical route to functionalized conjugated 1,3‐enynes and 1,3‐dienes is described. 1,4‐Bis(heteroaryl)‐1,3‐diene and 1‐heteroarylbut‐1‐en‐3‐yne derivatives were prepared from 1,4‐dichloro‐2‐butyne and corresponding N ‐heteroarenes such as imidazole, pyrrole, pyrazole and indole derivatives in the presence of bases in good to high yields.