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Kinetic Resolution of 2‐Chloro‐1‐(3,4‐dichlorophenyl)ethanol by Lipase‐Catalyzed Transesterification
Author(s) -
WANG MingHui,
LI YaFeng,
LIU YongJun,
ZHANG ShuSheng
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790314
Subject(s) - chemistry , kinetic resolution , transesterification , lipase , triethylamine , ethanol , catalysis , organic chemistry , base (topology) , resolution (logic) , triacylglycerol lipase , enzyme , medicinal chemistry , enantioselective synthesis , mathematical analysis , mathematics , artificial intelligence , computer science
Kinetic resolution of racemic 2‐chloro‐1‐(3,4‐dichlorophenyl)ethanol was performed by free Alcaligene sp. lipase‐catalyzed irreversible transesterification affording the ( R )‐isomer with ≧ 95% ee and the ( S )‐isomer with ≧ 90% ee . The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly.