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Nitration Reaction Catalyzed by Horseradish Peroxidase in the Presence of H 2 O 2 and NaNO 2
Author(s) -
DAI RongJi,
HUANG Hui,
CHEN Jie,
DENG YuLin,
XIAO ShengYuan
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790312
Subject(s) - nitration , chemistry , horseradish peroxidase , phenol , nitrophenol , hydroquinone , catechol , p cresol , catalysis , nitro , cresol , solvent , nuclear chemistry , nitro compound , organic chemistry , enzyme , alkyl
The enzymatic nitration of phenol and m ‐cresol catalyzed by horseradish peroxidase was studied in the presence of H 2 O 2 and NaNO 2 . The results showed that the nitration products of phenol were 2‐nitro and 4‐nitrophenols. There was also a small amount of by‐products of hydroquinone and catechol. The influences of various reaction parameters, including pH, organic solvent type, and concentrations of NaNO 2 and H 2 O 2 , on the nitration products were investigated. The yields of 4‐nitrophenol and 2‐nitrophenol were 14% and 12%, respectively. The nitration products of m ‐cresol were 4‐nitro‐ m ‐cresol and 6‐nitro‐ m ‐cresol, and the yields of 4‐nitro‐ m ‐cresol and 6‐nitro‐ m ‐cresol were 19% and 30%, respectively.
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