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Synthesis of Diphenyl α ‐(Dipropoxyphosphoramido)alkylphosphonates
Author(s) -
CUI ZhanWei,
ZHANG JianFeng,
MIAO ZhiWei,
CHEN RuYu
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790285
Subject(s) - chemistry , benzaldehyde , triphenyl phosphite , phosphoramidate , phosphonate , alkyl , organic chemistry , chloride , reaction conditions , medicinal chemistry , catalysis , stereochemistry
Abstract A convenient method has been developed for the synthesis of diphenyl α ‐(dipropoxyphosphoramido)alkyl‐ phosphonates under mild conditions, namely the reaction of dipropyl phosphoramidate ( 1 ) with a para ‐ (un)substituted benzaldehyde or cyclicketone ( 2 ) and triphenyl phosphite ( 3 ) by a one‐pot procedure with the aid of acetyl chloride.