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Characterization, Crystal Structure and Initial DNA Binding Interaction of Two Cu(II) Complexes with 4,5‐Diazafluoren‐9‐one
Author(s) -
SONG YanHong,
ZHANG RongLan,
SUN QingJin,
XU ZhanWei,
GAO QuanChang,
LIU HuaQiang,
ZHAO JianShe
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790278
Subject(s) - chemistry , intercalation (chemistry) , steric effects , crystallography , single crystal , dna , crystal structure , stereochemistry , spectral line , inorganic chemistry , biochemistry , physics , astronomy
Two new complexes [Cu(dafo) 2 (en)](ClO 4 ) 2 ·2H 2 O (en=NH 2 CH 2 CH 2 NH 2 ) 1 and [Cu(dafo) 2 (dap)](ClO 4 ) 2 · 2H 2 O [dap=NH 2 CH 2 CH(CH 3 )NH 2 ] 2 (dafo=4,5‐diazafluoren‐9‐one) have been synthesized and characterized by elemental analysis, IR and UV spectra. Meanwhile, the complex 1 has been characterized by single crystal X‐ray diffraction analysis. The initial DNA binding interactions of the complexes 1 and 2 have been investigated by UV spectra, emission spectra and cyclic voltammogram. Concluding the results of three methods used to measure the interaction of complexes 1 and 2 with DNA, the action mode of the two complexes with DNA is intercalation, and character of ligands and steric effect may affect the interaction of the complexes with DNA.