Premium
Effect of Concentration of Structurally‐Different Carboxylic Acids on Growth and Aggregation of Calcium Oxalate in Gel Systems
Author(s) -
Deng SuiPing,
Ouyang JianMing
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790255
Subject(s) - chemistry , oxalate , citric acid , calcium oxalate , calcium , carboxylic acid , tartaric acid , acetic acid , tartrate , nuclear chemistry , medicinal chemistry , inorganic chemistry , organic chemistry
The effect of concentration of structurally‐different carboxylic acids such as ethylene diamine tetraacetic acid (H 4 edta), citric acid (H 3 cit), tartaric acid (H 2 tart), and acetic acid (HOAc) on growth and aggregation of calcium oxalate (CaOxa) in gel systems was comparatively investigated. H 2 tart and H 3 cit could change the morphology of calcium oxalate monohydrate (COM) and induce the formation of calcium oxalate dihydrate (COD). H 4 edta could induce the formation of COD at a lower concentration of 0.33 mmol/L and have the strongest ability to inhibit aggregation of COM. HOAc inhibited COM aggregation only at a higher concentration than 500 mmol/L. With increasing the number of carboxylic groups in an acid or increasing the concentration of carboxylic acid, the capacity of this acid to induce COD formation and to inhibit growth and aggregation of COM crystals increased. That is, this capacity followed the order:H 4 edta>H 3 cit>H 2 tart>>HOAc. The result in this work suggested that the presence of H 3 cit and H 2 tart in urine played a role in the natural defense against stone formation.