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Inhibition of Homo‐coupling of Arylboronic Acids in Ligand Free Pd(II)‐Catalyzed Suzuki Reaction
Author(s) -
Tao XiaoChun,
Zhang YuePing,
He TianXiong,
Shen Dong
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790246
Subject(s) - phenylboronic acid , chemistry , suzuki reaction , ligand (biochemistry) , catalysis , combinatorial chemistry , coupling (piping) , palladium , coupling reaction , organic chemistry , biochemistry , receptor , mechanical engineering , engineering
A series of solvents were examined for the ligand free Pd(II)‐catalyzed Suzuki reaction of 4‐bromotoluene with phenylboronic acid. It was found that the PdCl 2 / i ‐PrOH system could efficiently inhibit the homo‐coupling of phenylboronic acid and give a cross‐coupling product in high yields. The substrates with a wide variety of functional groups were tolerated in the system. A possible mechanism for this system was proposed.