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Highly Efficient Pd/C‐Catalyzed Suzuki Coupling Reaction of p ‐(un)Substituted Phenyl Halide with ( p ‐Substituted phenyl) Boronic Acid
Author(s) -
Hu MingGang,
An ZhongWei,
Du WeiSong,
Li Jian,
Gao AiAi
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790220
Subject(s) - chemistry , halide , catalysis , boronic acid , bromide , palladium , suzuki reaction , coupling reaction , solvent , combinatorial chemistry , reaction conditions , medicinal chemistry , organic chemistry , polymer chemistry
A highly efficient Pd/C‐catalyzed ligandless, heterogeneous Suzuki reaction of p ‐(un)substituted phenyl halide with ( p ‐substituted phenyl)boronic acid in DMF/H 2 O solvent in a short reaction time (0.5 h) at 75 °C was developed. The key for such a catalytic system was the addition of 1 equivalent of tetrabutylammonium bromide. A wide variety of substituents can be tolerated and high yields of cross coupling products were achieved. The palladium catalyst can be easily recovered and reused without significantly decreasing its efficiency.