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L ‐Prolinamide Catalyzed Aqueous Direct Aldol Reaction: an Environment‐friendly Method for the Synthesis of β ‐Hydroxylketones
Author(s) -
Peng YiYuan,
Liu Han,
Cui Ming,
Cheng JinPei
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790187
Subject(s) - chemistry , environmentally friendly , aldol reaction , catalysis , substrate (aquarium) , aqueous medium , organic chemistry , simplicity , combinatorial chemistry , reaction conditions , aqueous solution , ecology , philosophy , oceanography , epistemology , biology , geology
An environment‐friendly L ‐prolinamide catalyzed aldol reaction has been developed. The reaction exhibited broad substrate generality,and high yields with good diastereoselectivity were obtained for cyclic ketones. The simplicity of product isolation, usage of water as environmentally benign reaction medium, and the usage of cheap, readily available and recyclable catalyst make this process promising to be developed for large‐scale preparation of β ‐hydroxyl ketones.