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Liquid‐Phase Synthesis of Methyl (2 Z )‐2‐Arylsulfonylmethyl‐2‐ alkenoates from PEG‐Supported α ‐Phenylselenopropionate
Author(s) -
Wang Qiong,
Sheng ShouRi,
Lin ShuYing,
Guo Lei,
Wei MeiHong,
Huang Xian
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790164
Subject(s) - chemistry , peg ratio , hydrogen peroxide , derivative (finance) , medicinal chemistry , sodium , organic chemistry , finance , financial economics , economics
Treatment of lithio derivative of novel PEG‐supported (‐phenylselenopropionate with aldehydes, followed by oxidation‐elimination with 30% hydrogen peroxide, formed Baylis‐Hillman products, which were then reacted with sodium arylsulfinate. The resulting sulfonylated products were cleaved from the PEG efficiently affording methyl (2 Z )‐2‐arylsulfonylmethyl‐2‐alkenoates in good yields and high purities.