Catalytic Hydrogenation of  α , β ‐Epoxyketones to  β ‐Hydroxy‐ ketones with Two Sulfinyl Analogues of Coenzyme NADH Models | Zendy

Xie Kun | Zendy; Cui Yi | Zendy; Liu YouCheng | Zendy; Fu Yao | Zendy

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Catalytic Hydrogenation of α , β ‐Epoxyketones to β ‐Hydroxy‐ ketones with Two Sulfinyl Analogues of Coenzyme NADH Models

Author(s) -

Xie Kun,

Cui Yi,

Liu YouCheng,

Fu Yao

Publication year - 2007

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200790154

Subject(s) - chemistry , catalysis , nad+ kinase , cofactor , ketone , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , enzyme

An efficient method for the selective hydrogenation of a series of α , β ‐epoxyketones to β ‐hydroxyketones using catalytic amount of two sulfinyl analogues of NAD + model compounds is reported. The lack of any diastereoselectivity for the formation of β ‐hydroxyketones with optically pure sulfinyl analogue of NAD + model supports the radical mechanism proposed previously.

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