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Catalytic Hydrogenation of α , β ‐Epoxyketones to β ‐Hydroxy‐ ketones with Two Sulfinyl Analogues of Coenzyme NADH Models
Author(s) -
Xie Kun,
Cui Yi,
Liu YouCheng,
Fu Yao
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790154
Subject(s) - chemistry , catalysis , nad+ kinase , cofactor , ketone , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , enzyme
An efficient method for the selective hydrogenation of a series of α , β ‐epoxyketones to β ‐hydroxyketones using catalytic amount of two sulfinyl analogues of NAD + model compounds is reported. The lack of any diastereoselectivity for the formation of β ‐hydroxyketones with optically pure sulfinyl analogue of NAD + model supports the radical mechanism proposed previously.