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Synthesis and Bio‐activities of Pyrazolyl or Pyridinyl Substituted Tonghaosu Analogs
Author(s) -
Yin BiaoLin,
Chen Li,
Xu HanHong,
Zhang JianCun,
Wu YuLin
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790148
Subject(s) - chemistry , spodoptera litura , pieris brassicae , culex quinquefasciatus , stereochemistry , larva , botany , aedes aegypti , biology
11 pyrazolyl or pyridinyl substituted tonghaosu analogs were synthesized. Structures of all the new compounds were confirmed by 1 H NMR, IR, MS, HREIMS or elemental analysis. Their antifeedant activity against larvae of large white butterfly ( Pieris brassicae L.), larvicidal activity toward mosquito ( Culex quinquefasciatus Say) and growth control activity toward larvae of Spodoptera litura Fab were examined. Some of them exhibited antifeeding activities comparable to or stronger than tonghaosu Z‐1 . Based on the activity data, the preliminary structure‐activity relationship was also discussed, which might be instructive for finding out lead compounds with better bioactivities in the future.