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Highly Efficient One‐Pot Synthesis of 2‐Arylmethyl N ‐Substituted Anilines via Yb(OTf) 3 Catalyzed Three‐Component Reaction
Author(s) -
Wang LiMin,
Zhang Liang,
Hu Liang,
Tian He
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790071
Subject(s) - chemistry , catalysis , component (thermodynamics) , primary (astronomy) , reaction conditions , combinatorial chemistry , coupling reaction , organic chemistry , medicinal chemistry , physics , astronomy , thermodynamics
An efficient method has been developed for one‐pot three‐component coupling reactions of various aldehydes, 1‐cyclohexen‐2‐one, and primary or secondary amines in the presence of a catalytic amount of Yb(OTf) 3 under mild conditions to afford the corresponding 2‐arylmethyl N ‐substituted anilines in good yields. In addition, the catalyst was easily recovered and could be reused for at least four cycles without any loss of activity.