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Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2′,1′:5,1]pyrazolo[4,3‐ d ]pyrimidin‐4‐one Derivatives
Author(s) -
Tian GuangHui,
Xia GuangXin,
Jin WeiXi,
Chen XinJian,
Lai ShunAn,
Wei YaBing,
Ji RuYun,
Shen JingShan
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790048
Subject(s) - chemistry , inhibitory postsynaptic potential , sildenafil , stereochemistry , combinatorial chemistry , neuroscience , biology , medicine
Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.