Premium
Biocatalytic Synthesis of Highly Enantiopure 1,4‐Benzodioxane‐2‐carboxylic Acid and Amide
Author(s) -
Liu Jun,
Wang DeXian,
Zheng QiYu,
Wang MeiXiang
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690312
Subject(s) - nitrile hydratase , chemistry , enantiopure drug , amidase , nitrile , amide , carboxylic acid , catalysis , organic chemistry , enantioselective synthesis , methanol , combinatorial chemistry , enzyme
Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole‐cell catalyst, at 10 °C and with the use of methanol as a co‐solvent, nitrile and amide biotransformations produce 2 S ‐1,4‐benzodioxane‐2‐carboxamide and 2 R ‐1,4‐benzodioxane‐2‐carboxylic acid in high yields with excellent enantioselectivity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom