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Biocatalytic Synthesis of Highly Enantiopure 1,4‐Benzodioxane‐2‐carboxylic Acid and Amide
Author(s) -
Liu Jun,
Wang DeXian,
Zheng QiYu,
Wang MeiXiang
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690312
Subject(s) - nitrile hydratase , chemistry , enantiopure drug , amidase , nitrile , amide , carboxylic acid , catalysis , organic chemistry , enantioselective synthesis , methanol , combinatorial chemistry , enzyme
Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole‐cell catalyst, at 10 °C and with the use of methanol as a co‐solvent, nitrile and amide biotransformations produce 2 S ‐1,4‐benzodioxane‐2‐carboxamide and 2 R ‐1,4‐benzodioxane‐2‐carboxylic acid in high yields with excellent enantioselectivity.