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A Fast Assembly of (−)‐Epigallocatechin‐3‐gallate [(−)‐EGCG] via Intra‐ and Inter‐molecular Mitsunobu Reaction
Author(s) -
Ding TongJian,
Wang XiaoLong,
Cao XiaoPing
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690303
Subject(s) - chemistry , dihydroxylation , mitsunobu reaction , yield (engineering) , cinnamyl alcohol , derivative (finance) , combinatorial chemistry , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , cinnamaldehyde , materials science , economics , financial economics , metallurgy
This paper described a concise construction of (−)‐EGCG ( 1f ) (with an overall yield of 20% for seven steps based on the starting cinnamyl alcohol derivative 3 ), featuring asymmetric dihydroxylation (ADH), intra‐ and inter‐ molecular Mitsunobu reaction as key steps. Our strategy disclosed herein constitutes a new effective general synthetic approach toward the analogues of (−)‐EGCG ( 1f ).
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