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A New Route to Z ‐5‐Fluoro‐2‐methyl‐1‐( p ‐methylsulfinylbenzylidene)‐3‐indenylacetic Acid and Its X‐ray Diffraction Analysis
Author(s) -
Zeng Zhuo,
Chen ChaoSen,
Jin GuiFang,
Zhao JingWei,
Zhu ShiZheng
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690271
Subject(s) - chemistry , sulindac , intermolecular force , hydrogen bond , acetic acid , bromide , x ray , crystallography , diffraction , x ray crystallography , crystal structure , single crystal , stereochemistry , molecule , organic chemistry , medicine , physics , quantum mechanics , nonsteroidal , optics , pharmacology
The title compound (Sulindac) was prepared from the corresponding sulfinyl compound p ‐methylsulfinylbenzyl bromide by four‐step reaction. The sole product ( Z )‐5‐fuoror‐2‐methyl‐1‐( p ‐methylsulfinylbenzylidene)‐3‐indenyl acetic acid (Sulindac) was obtained and the E isomer of it was not found. X‐ray single crystal diffraction analysis showed that the strong intermolecular hydrogen bonding and weak intermolecular hydrogen bonding coexisted in Sulindac.