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Indium Trichloride‐Mediated Facile Synthesis of 3‐(Substituted methylthio)‐4‐phenyl‐5‐(3,4,5‐trimethoxyphenyl)‐4 H ‐1,2,4‐triazole in Water †
Author(s) -
Yang Song,
Song BaoAn,
Jin LinHong,
Hu DeYu
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690235
Subject(s) - chemistry , indium , aqueous medium , halide , triazole , 1,2,4 triazole , medicinal chemistry , organic chemistry , aqueous solution , combinatorial chemistry
An environmentally benign and efficient process for the preparation of 3‐(substituted methylthio)‐4‐phenyl‐5‐ (3,4,5‐trimethoxyphenyl)‐4 H ‐1,2,4‐triazole was achieved by the reaction of 4‐phenyl‐5‐(3,4,5‐trimethoxyphenyl)‐ 4 H ‐1,2,4‐triazole‐3‐thiol with different halides in aqueous media mediated by indium trichloride in high yields.