Design of Multivalent Galactoside Ligands and Their Binding to Hepatic Asialoglycoprotein Receptor | Zendy

Zhang XiaoRu | Zendy; Jia JiLong | Zendy; Zhang RongJun | Zendy; Xu MinHua | Zendy; Zhang ShuSheng | Zendy

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Design of Multivalent Galactoside Ligands and Their Binding to Hepatic Asialoglycoprotein Receptor

Author(s) -

Zhang XiaoRu,

Jia JiLong,

Zhang RongJun,

Xu MinHua,

Zhang ShuSheng

Publication year - 2006

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200690197

Subject(s) - galactosides , asialoglycoprotein receptor , chemistry , galactoside , divalent , receptor , in vitro , binding site , stereochemistry , biochemistry , combinatorial chemistry , galactose , organic chemistry , enzyme , hepatocyte

In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor (ASGPR), four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro . The results showed that trivalent cluster galactosides behaved better than divalent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity than those with aliphatic chain scaffolds.

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