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Design of Multivalent Galactoside Ligands and Their Binding to Hepatic Asialoglycoprotein Receptor
Author(s) -
Zhang XiaoRu,
Jia JiLong,
Zhang RongJun,
Xu MinHua,
Zhang ShuSheng
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690197
Subject(s) - galactosides , asialoglycoprotein receptor , chemistry , galactoside , divalent , receptor , in vitro , binding site , stereochemistry , biochemistry , combinatorial chemistry , galactose , organic chemistry , enzyme , hepatocyte
Abstract In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor (ASGPR), four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro . The results showed that trivalent cluster galactosides behaved better than divalent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity than those with aliphatic chain scaffolds.