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Synthesis of Styryl‐substituted Z/E ‐Chlorin Derivatives with Chlorophyll‐ a Skeleton
Author(s) -
Wang JinJun,
Li JiaZhu,
Wu XuRan,
Shim Yong Key
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690177
Subject(s) - chemistry , chlorin , wittig reaction , reagent , yield (engineering) , bromide , nickel , phosphorus trichloride , chloride , medicinal chemistry , organic chemistry , photodynamic therapy , materials science , metallurgy
The Wittig reaction of methyl pyropheophorbide‐ d 2 , obtained from methyl pyropheophorbide‐ a 1 , with benzyltriphenylphosphonium bromide was performed to yield isomers 3a and 3b . The Vilsmeier reaction of nickel complex 4 or 7 with 3‐dimethylaminoacrolein in the presence of phosphoryl chloride was carried out to form 20‐ meso ‐2′‐formylvinylpyropheophorbide ‐a 5 or 8 , which was reacted with Wittig reagent to afford nickel complex isomers 6a and 6b or 9a and 9b , 10a and 10b .
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