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Reduction of Azide to Amine Using Fe/AlCl 3 or Fe/BiCl 3 System in Aqueous EtOH
Author(s) -
Zheng PengWu,
Xie XueMin,
Wang Wei,
Wang XiaoJi,
Guo YuPing,
Tu QiDong
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690157
Subject(s) - chemistry , aqueous solution , amine gas treating , azide , ethanol , lewis acids and bases , reduction (mathematics) , metal , inorganic chemistry , organic chemistry , catalysis , geometry , mathematics
Azides were reduced to the corresponding amines by two new metal/Lewis acid systems in aqueous EtOH with yields ranging from 80% to 95%. The new reduction systems were Fe/AlCl 3 ·6H 2 O or Fe/BiCl 3 system in H 2 O/ethanol (2:1, V : V ) at room temperature. Fifteen azides with different functional groups were well reduced to the corresponding amines in excellent yields.