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One Pot Reduction of Imines Generated in ‐ situ from Aldehydes and Amines by the NaBH 4 ‐InCl 3 System
Author(s) -
Ravi Varala,
Ramu Enugala,
Vijay kumar Ponnamaneni,
Srinivas rao Adapa
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690153
Subject(s) - chemistry , sodium borohydride , acetonitrile , catalysis , in situ , halogen , carbon fibers , primary (astronomy) , organic chemistry , functional group , combinatorial chemistry , medicinal chemistry , alkyl , materials science , physics , astronomy , composite number , composite material , polymer
A combination of sodium borohydride and a catalytic amount of indium(III) chloride in acetonitrile reduces imines formed in‐situ from aldehydes and amines to the corresponding functionalised secondary and tertiary amines in moderate to good yields. Noteworthy is that highly chemoselective reactions were achieved in the presence of other functional groups such as halogens, carbon‐carbon double bonds and hydroxyl groups.