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Spectroscopic Study on Interaction of β ‐Cyclodextrin with Triprolidine Hydrochloride
Author(s) -
Ali Syed Mashhood,
Asmat Fahmeena
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690127
Subject(s) - chemistry , cyclodextrin , hydrochloride , ring (chemistry) , intermolecular force , inclusion compound , stoichiometry , stereochemistry , medicinal chemistry , crystallography , molecule , organic chemistry
The complexation of triprolidine hydrochloride (TRP) and β ‐cyclodextrin ( β ‐CD) in deuterium oxide was investigated by 400 MHz 1 H NMR spectroscopy. The 800 MHz 2D ROESY data revealed that two 1:1 and one 2:1 β ‐CD‐TRP inclusion complexes were formed. Both aromatic moieties ( p ‐tolyl and pyridyl ring) has entered into the β ‐CD cavity, confirming the existence of two different equilibria for 1:1 inclusion complexes in which p ‐tolyl ring of the guest is more tightly held by the host cavity. The ROE intermolecular interactions provided the plausible structures of these 1:1 and 2:1 stoichiometric inclusion complexes of β ‐CD‐triprolidine hydrochloride in solution.