Premium
Convenient Synthesis of Indene Derivatives via Intramolecular Friedel‐Crafts Cyclization of Tetraaryl Substituted 1,3‐Butadienes
Author(s) -
Sun Xun,
Izumi KenJi,
Hu ChangQi,
Lin GuoQiang
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690082
Subject(s) - chemistry , indene , friedel–crafts reaction , regioselectivity , intramolecular force , lewis acids and bases , double bond , medicinal chemistry , organic chemistry , catalysis
A convenient and efficient method for the highly regioselective synthesis of indene derivatives 4 and 5 from tetraaryl substituted 1,3‐butadienes 3 was described. The method involves an intramolecular Friedel‐Crafts cyclization and a corresponding double‐bond positional shift of isomers 4 and 5 in the presence of different Lewis acids under mild conditions with higher than 90% yields.