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Rapid Synthesis of 1,2,3,4‐Tetrahydropyrimidin‐2‐ones Using Zn(NH 2 SO 3 ) 2 as a Catalyst under Microwave Irradiation
Author(s) -
Zhang Min,
Li YiQun,
Zhou MeiYun
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690054
Subject(s) - chemistry , thiourea , microwave irradiation , catalysis , urea , zinc , microwave , irradiation , organic chemistry , nuclear chemistry , physics , quantum mechanics , nuclear physics
Abstract Rapid synthesis of 1,2,3,4‐tetrahydropyrimidin‐2‐ones (THPO) from aromatic aldehydes, β ‐ketoester and urea (or thiourea) using zinc sulfamate as the catalyst under microwave irradiation was described here. Compared with the classical Biginelli reaction, this new method consistently has the advantages of good yields (76%–96%), short reaction time (3–15 min), no corrosion to equipments, ease of manipulation, and low cost catalyst.