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Oxidant Promoted 1,3‐Dipolar Cycloaddition of Pyridinium Ylides to Chalcones for Preparation of 1‐Benzoyl‐2‐arylindolizines
Author(s) -
Wang BingXiang,
Liu WeiWei,
He Ting,
Hu HongWen
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690053
Subject(s) - chemistry , pyridinium , cycloaddition , 1,3 dipolar cycloaddition , medicinal chemistry , organic chemistry , catalysis
The derivatives of 1‐benzoyl‐2‐arylindolizine were prepared in moderate yields of 41%–78% by CrO 3 /Et 3 N promoted 1,3‐dipolar cycloaddition of pyridinium N ‐ylides and chalcones. Under the same conditions, CrO 3 /Et 3 N promoted 1,3‐dipolar cycloaddition of isoquinolinium N ‐ylides and chalcones provided the corresponding 1‐benzoyl‐2‐arylpyrrolo[2,1‐ a ]isoquinolines in 45%–61% yields.