Premium
Studies on the Physicochemical Properties, Structure and Antitumor Activity of Polysaccharide YhPS‐1 from the Root of Cordalis yanhusuo Wang
Author(s) -
Tao YiWen,
Tian GengYuan
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690045
Subject(s) - chemistry , polysaccharide , gel permeation chromatography , chromatography , monosaccharide , composition (language) , carbohydrate , chemical structure , organic chemistry , polymer , philosophy , linguistics
A polysaccharide named YhPS‐1 was isolated from the root of Cordalis yanhusuo Wang and purified by means of gel‐permeation chromatography and ionexchange chromatography. Its physicochemical properties, including monosaccharide composition, carbohydrate content, molecular weight and elemental composition, were determined. The structure of YhPS‐1 was elucidated by chemical methods along with 1 H and 13 C NMR spectroscopy ways, such as including two‐dimensional HMQC and HMBC experiments. These results show that YhPS‐1 possesses a backbone consisting of terminal α ‐Glc p ‐(1→, α ‐Glc p ‐(1→6), α ‐Glc p ‐(1→4) and α ‐Glc p ‐(1→4,6). The bioactive assay showed that it could inhibit the growth of Sarcoma 180 and Lewis pulmonary carcinoma implanted in mice.