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Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Titanium(IV) Complexes of N ‐Sulfonylated β ‐Amino Alcohols
Author(s) -
Wang ShaoHua,
Tu YongQiang,
Chen Peng
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690031
Subject(s) - chemistry , enantioselective synthesis , phenylacetylene , propargyl alcohol , catalysis , propargyl , titanium , organic chemistry , alcohol
Abstract The easily prepared and recoverable chiral N ‐sulfonylated β ‐amino alcohol 2 in combination with Ti(OPr‐ i ) 4 was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, i.e. chiral tertiary propargyl alcohols, with the ee up to 92%.