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Microbial Hydroxylation of Quinovic Acid Glycoside by Streptomyces griseus ACCT 13273
Author(s) -
Cheng ZhiHong,
Yu BoYang,
Guo YinLong,
Qiu ShengXiang
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690028
Subject(s) - chemistry , hydroxylation , streptomyces griseus , biotransformation , glycoside , metabolite , triterpene , stereochemistry , transformation (genetics) , organic chemistry , biochemistry , streptomyces , enzyme , bacteria , medicine , alternative medicine , pathology , biology , gene , genetics
Abstract Microbial transformation of a triterpene glycoside, quinovic acid 3‐ O ‐ β ‐ D ‐quinovopyranoside by Streptomyces griseus ACCT 13273 was achieved with the aim of generating new bio‐active derivatives. Preparative‐scale biotransformation with standard two‐stage fermentation protocol afforded a new oxidized metabolite, as a result of the hydroxylation of the methyl group at C‐30, which was difficult to achieve by chemical means. The metabolite was elucidated based on extensive NMR and high‐resolution mass spectral analyses.