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A Rapid and Convenient Synthetic Route to Novel 1,5‐Benzodiazepine Derivatives of 5‐Methyl‐3‐phenyl‐2‐oxo‐Δ 4 ‐1,3,4‐oxadiazolines from p ‐Acetylphenylsydnone and Their Pharmacological Activity
Author(s) -
Kamble Ravindra R.,
SUDHA Belagur S.
Publication year - 2006
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200690025
Subject(s) - chemistry , microwave irradiation , yield (engineering) , microwave , benzodiazepine , combinatorial chemistry , computational chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , materials science , physics , receptor , quantum mechanics , metallurgy
A simple and high yielding method for the integration of 1,5‐benzodiazepines integrated with 5‐methyl‐2‐oxo‐3‐phenyl‐Δ 4 ‐1,3,4‐oxadiazolines in 75%–90% yield by microwave irradiation is devised. Microwave‐accelerated reaction was compared with thermal method. All the compounds were characterized by physical, analytical and spectral (IR, 1 H NMR, MS) data. Title compounds were screened for preliminary pharmacological activities.