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Synthesis and Biological Evaluation of a New Category of Purine‐Nucleoside Analogues
Author(s) -
Li DaLiang,
Bao HongLi,
Tan QiTao,
Tan YuPing,
You TianPa
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200591659
Subject(s) - chemistry , imidazole , purine , moiety , nucleoside , residue (chemistry) , stereochemistry , combinatorial chemistry , nitroimidazole , nucleic acid , benzimidazole , coupling reaction , nucleoside analogue , organic chemistry , biochemistry , enzyme , catalysis
Convenient procedure for coupling of 1,2,3,5‐tetra‐ O ‐acetyl‐ β ‐ D ‐ribofuranose and 4‐nitroimidazole was provided to obtain β ‐anomer as major product. A novel category of nucleoside analogues with an imidazole base moiety bearing amino‐acid residue was designed and synthesized to develop selective and effective antiviral agents. They were evaluated for the anti‐HBV activity.