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Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity
Author(s) -
Zhang YiChun,
Chen PingTao,
Guan HuaShi,
Li YingXia
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200591523
Subject(s) - chemistry , conjugate , lipid peroxidation , antioxidant , dpph , in vitro , potency , croton oil , pharmacology , biochemistry , inflammation , medicine , mathematical analysis , mathematics
Abstract A series of new conjugates of indomethacin with phenolic antioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidation significantly, while 11b–11e and 13b–13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.