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Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing 2‐Methylidenethiazolidine Ring
Author(s) -
Xu LiangZhong,
Li WeiHua,
Si GuoDong,
Li Kai,
Yang ShuangHua,
Hou BaoRong
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200591449
Subject(s) - chemistry , ring (chemistry) , triazole , 1,2,4 triazole , stereochemistry , combinatorial chemistry , organic chemistry
The two compounds 1‐[1‐(2′,4′‐dichlorobenzoyl)‐1‐(3‐phenylthiazolidin‐2‐ylidene)methyl]‐1,2,4‐triazole ( 3a ) and 1‐[1‐(4′‐fluorobenzoyl)‐1‐(3‐phenylthiazolidin‐2‐ylidene)methyl]‐1,2,4‐triazole ( 3b ) were prepared by reaction of phenyl isothiocyanate, 1,2‐dibromoethane with α ‐(1,2,4‐triazol‐1‐yl)‐substituted‐acetylbenzene. Their structures were identified by means of elemental analysis, IR, and 1 H NMR spectra. The single crystal of compound 3b was also obtained. It crystallizes in triclinic system with space group $ P {\bar 1} $ and a =0.9390(2) nm, b =0.9661(2) nm, c =1.0929(2) nm, α =111.53(3)°, β =100.46(3)°, γ =102.08(3)°, Z =2, V =0.8647(3) nm 3 , D c =1.407 g/cm 3 , μ =0.213 mm −1 , F (000)=380, final R 1 =0.073. There is obvious potentially weak CH···Y (Y=N, F, O) intermolecular interaction between the molecules in the crystal lattice, which stabilizes the crystal structure. The result of the biological test showed that the two compounds have certain fungicidal activities.