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Penta‐Coordinate Phosphorus Intermediates Analysis on Phospho‐related Proteins
Author(s) -
Li Wu,
Ma Yuan,
Zhao YuFen
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200591264
Subject(s) - chemistry , square pyramid , phosphorus , trigonal bipyramidal molecular geometry , pyramid (geometry) , protein data bank (rcsb pdb) , crystal structure , amino acid , phosphorylation , crystallography , stereochemistry , biochemistry , organic chemistry , physics , optics
In this paper, based on known crystal structures of square pyramid (SP) and trigonal bipyramid (TBP) penta coordinated phosphorus compounds containing amino acid side chains, such as amino, carboxyl, hydroxyl or thiol, a software for survey the P(5)‐structure of phosphorylated proteins was derived. By this software, it was found that 382 of 398 phosphorus related kinases (96%) from current PDB could go through the penta‐coordinated phosphorus transition state or intermediate.