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Improved Procedure for Preparation of Covalently Bonded Cellulose Tris‐phenylcarbamate Chiral Stationary Phases
Author(s) -
Feng Qin,
XiaoMing Chen,
YueQi Liu,
HanFa Zou,
JunDe Wang
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590885
Subject(s) - chemistry , cellulose , covalent bond , reagent , derivative (finance) , organic chemistry , polymer chemistry , economics , financial economics
The classical method for preparation of covalently boned cellulose derivative chiral stationary phases (CSP) with diisocyanate as spacer was improved. Diisocyanate was firstly allowed to react with 3‐aminopropyltriethoxysilane, and the resulting product was then applied as the spacer reagent to immobilize cellulose derivatives onto silica gel. Influences of the amount and the length of the spacer on the optical resolution ability of the CSP were investigated. Comparing improved procedure to classical diisocyanate method, the cross‐linking between the glucose units of the cellulose derivatives was avoided to the most extent. With the improved procedure, regio‐nonselective ways could be adopted to prepare covalently bonded CSP, which showed an advantage for the rapid preparation.