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Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing Thioamide Group
Author(s) -
FaQian Liu,
YongQi Qin,
LiangZhong Xu,
LuDe Lu,
XuJie Yang,
Xin Wang
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590881
Subject(s) - chemistry , thioamide , monoclinic crystal system , crystal structure , isothiocyanate , triazole , crystallography , acetophenone , antifungal , stereochemistry , thioacetamide , intermolecular force , medicinal chemistry , molecule , organic chemistry , catalysis , medicine , biochemistry , dermatology
Two compounds 2‐benzoyl‐ N ‐phenyl‐2‐(1,2,4‐triazol‐1‐yl)thioacetamide ( 1 ) and 2‐(4‐chlorobenzoyl)‐ N ‐phenyl‐ 2‐(1,2,4‐triazol‐1‐yl)thioacetamide ( 2 ) were synthesized from substituted acetophenone, triazole and phenyl isothiocyanate by several step reactions. The structure of compound 1 was determined by single‐crystal X‐ray diffraction analysis. It crystallizes in monoclinic system with space group P2 1 / c , a =0.8806(2) nm, b =1.2097(2) nm, c =1.4809(3) nm, β=105.88°, Z =4, V =1.5173(6) nm 3 , Dc=1.411 Mg/m 3 , μ=0.22 mm ‐1 , F (000)=672, final R 1 =0.040 and R w =0.103. There is obvious potentially weak CH···N intermolecular interaction in the crystal, which stabilizes the structure. The results of biological test show that the two compounds have antifungal and plant growth regulating activities.