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Interactions with ATP, DNA Cleavage and Anti‐tumor Activities of Complexes with Anions [Mo(V)O 2 (O 2 C 6 H 4 ) 2 ] 3‐ , [Mo(V) 0.5 W(VI) 0.5 O 2 (O 2 C 6 H 4 ) 2 ] 2.5‐ and [W(VI)O 2 (O 2 C 6 H 4 ) 2 ] 2‐
Author(s) -
XiaoMing Lu,
Ling Jiang,
XiAn Mao,
ChaoHui Ye,
JingFen Lu,
JingRong Cui
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590781
Subject(s) - chemistry , molybdenum , cleavage (geology) , aqueous solution , hydrolysis , stereochemistry , crystallography , tungsten , crystal structure , dna , medicinal chemistry , redox , inorganic chemistry , organic chemistry , biochemistry , geotechnical engineering , fracture (geology) , engineering
(NH 3 CH 2 CH 2 NH 2 ) 3 [Mo(V)O 2 (O 2 C 6 H 4 ) 2 ] ( 1 ), (NH 3 CH 2 CH 2 NH 2 ) 2.5 [Mo(V) 0.5 W(VI) 0.5 O 2 (O 2 C 6 H 4 ) 2 ] ( 2 ) and (NH 3 CH 2 CH 2 NH 2 ) 2 [W(VI)O 2 (O 2 C 6 H 4 ) 2 ] ( 3 ) were synthesized, structurally characterized by X‐ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2 , while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3 . ATP promoted the oxidation of both molybdenum and tungsten from M(V) to M(VI) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S 180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti‐tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands.