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Physicochemical Characterization of Veronicafolin‐β‐cyclodextrin and Solubility Enhancement of Veronicafolin‐HP‐β‐cyclodextrin Inclusion Compound
Author(s) -
YunShang Yang,
YingPeng Zhang,
AiMei Yang,
RunHua Lu,
YanPing Shi,
GaoFeng Shi
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590775
Subject(s) - chemistry , solubility , cyclodextrin , gravimetric analysis , elemental analysis , inclusion compound , stability constants of complexes , phase diagram , phase (matter) , thermogravimetric analysis , nuclear chemistry , crystallography , chromatography , organic chemistry , aqueous solution
Inclusion complexation between veronicafolin, 3,5,4′‐trihydroxy‐6,7,3′‐trimethoxyflavone, and β‐cyclodextrin (β‐CD) was investigated by using 1 H NMR, IR, X‐ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1:1) of flavonol‐β‐CD·20H 2 O with C 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV‐Vis in solution in the presence of hydroxypfropyl‐β‐cyclodextrin (HP‐β‐CD) was classified as A L ‐type, indicating the formation of 1:1 inclusion complex. And the calibration equation y =24148 x +0.0075 ( r =0.9999) and phase‐solubility diagram y=0.4738x‐2.0×10 ‐7 (r=0.9490) were obtained. Stability constant K s was calculated from the phase solubility diagram (K s =4.5×10 6 ). Solubility of the veronicafolin was enhanced in the presence of HP‐β‐CD.