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Arenicolsterol A, a Novel Cytotoxic Enolic Sulfated Sterol from a Marine Annelid Arenicola cristata
Author(s) -
Bin Chen,
XianRong Shen,
JiLie Kong
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590599
Subject(s) - annelid , chemistry , sterol , hela , arenicola , cytotoxic t cell , cell culture , sulfation , stereochemistry , biochemistry , cell , zoology , biology , ecology , in vitro , genetics , cholesterol
Marine organisms are the important source of the bioactive metabolites. A novel enolic sulfated sterol, arenicolsterol A, has been isolated from a marine annelid Arenicola cristata collected in the coast of Mainland of China. The structure was elucidated using all sorts of spectroscopic data including ESIMS, 1D and 2D NMR etc . The cytotoxic bioactivity of this sterol was evaluated by MTT assay. It could inhibit the growth of human cervix cancer cell line (Hela) and human non‐small cell lung cancer cell line (NCI‐h6) with IC 50 of (3.1±0.6) µg/mL and (7.6±0.8) µg/mL.