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Syntheses of Benzimidazoles, Quinoxalines and 3,3‐Dihydro‐1 H ‐1,5‐benzodiazepines Starting from o ‐Phenylenediamine
Author(s) -
Yong Cui,
XiuBo Tang,
ChangXing Shao,
JiTai Li,
WenHua Sun
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590589
Subject(s) - chemistry , quinoxaline , o phenylenediamine , benzimidazole , ring (chemistry) , elemental analysis , medicinal chemistry , condensation , derivative (finance) , aryl , crystal structure , single crystal , proton nmr , condensation reaction , organic chemistry , stereochemistry , crystallography , catalysis , physics , alkyl , financial economics , economics , thermodynamics
A series of benzo‐fused heteroaromatic compounds with 5‐, 6‐ and 7‐membered rings, such as benzimidazole, quinoxaline and 1 H ‐1,5‐benzodiazepine derivatives, were synthesized through condensation reaction of o ‐phenylenediamine with aryl aldehydes or ketones. The experimental conditions were carefully examined, and the products were characterized by 1 H NMR, 13 C NMR, MS, IR and elemental analyses. In addition, the structure of a benzodiazaepine derivative with 7‐membered ring was confirmed by single crystal X‐ray diffraction analysis.