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Synthesis of 2,15‐Hexadecanedione as a Precursor of Muscone
Author(s) -
Yuan Guo,
Huan Gu,
Zhen Shi
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590334
Subject(s) - chemistry , salt (chemistry) , hydrolysis , organic chemistry , natural product , cofactor , biomimetic synthesis , iodide , methyl iodide , enzyme
Muscone is a precious fragrant compound scarce in nature. Many synthetic attempts for this unique natural product have been carried out. In this work, the one‐carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. Bisbenzimidazolium salt was used as tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of 2,15‐hexadecanedione, a precursor of muscone, was successfully accomplished by using the addition‐hydrolysis reaction of bisbenzimidazolium salt with methyl magnesium iodide.